XFEL Sample Injector · Hydrated Injection of Biomolecules into X-ray Free Electron Lasers (XFEL)

Building upon the Gas Dynamic Virtual (GDVN) technology developed by the researcher at his home institution and upon the very successful use of these injectors for biomolecular structure measurement with seminal X-ray Free Electron Lasers (XFEL's), this project will enhance and expand GDVN capabilities for both the current and the next generation of XFEL's. Specific goals of this project are (1) reduction of sample consumption from the 1-10 microliters/minute of the current GDVN injectors down to under 100 nanoliters/min, (2) development and testing of specific experimental methods (capillary coatings, new GDVN methodology, improved flow systems) to expand the variety of biological samples that can be delivered using GVDN injectors, and (3) porting of this technology and knowledge to the European XFEL communities.