RITTAR · RGS1 in intestinal T cell trafficking and responsiveness

The intestine is a challenging site for the immune system, which must balance the need to defend from pathogens, with the need to limit responses to commensals and to preserve tissue integrity. Nonetheless, few mechanisms have been defined by which the regulation of gut T cell responses may be distinguished from systemic T cell regulation. RGS1 is one of the most differentially expressed gene-products between gut-associated and lymphoid T cells, and yet there has been essentially no study of its biology in T cells. Preliminary studies of RGS1 biology have identified conspicuously high expression in gut-associated T cells