RadioClick · A versatile ultrafast Click platform for antibody based radio diagnostics

Diagnosing cancer as early as possible is one of the most powerful strategies in modern medicine to improvehuman well-being. Antibodies (Abs) are excellent molecules that can be used to target specific tumors. As Absrequire hours to days for accumulating on tumor surfaces, the use of Abs for nuclear imaging (such as PETimaging) is limited by the short half-lives of popular radioisotopes. Therefore, we plan to move the step of radiolabelingfrom the bench to the tumor itself. However, the entanglement of Abs with an artificial chemical probe isone of the most promising but at the same time one of the most technically challenging developmental areas inbiotechnology. Our unique approach is based on the production of “hybrid-Abs”, which combine in only one “click”step the power of synthetic chemistry with the best of biology (“custom-biologics”). Our unique selling points areultra-fast, exceptional bioorthogonal and specific labeling reactions in living organism as well as a both-sidedmodularity of the connection between Abs and chemical probe. By doing so, high contrast visualization of thecancer will become possible.