PHOTOCYLINDER · Photodynamic therapy enabled DNA-fork-binding metallo-cylinders: drugs and release triggers

This proposal will bring to Birmingham a highly promising early career researcher originally from India and now in Grenoble, to undertake an exciting project at the interface of chemistry, nanoscience and biology. The fellowship will develop the fellow to a position where he will be ready to secure an academic position to launch his own independendent research career in Bioinorganic Chemistry, supported by and further developing the European links and collaborations he will have formed. Alongside the research training in techniques and approaches and transferable skills training the fellow will gain, he will transfer to Birmingham his expertise in agents for photodynamic therapy, enhancing the capabilities of the Birmingham teams. The overarching research aims of this work are to develop for the first time DNA-fork-binding metallocylinders with a PDT capability and to use these not only as direct PDT agents but also as triggers to release therapeutic drugs from DNA nanostructures.