MultiphaseGTR · Bioactive multiphase membrane for periodontal regeneration

Periodontitis is one of the world's most prevalent chronic dental and maxillofacial diseases that will ultimately lead to unwanted tooth loss. This disease was responsible for a significant loss of 158.64 billion in Europe in 2018. Due to the complexity of the grafting treatment techniques, the efficiency of these procedures is notably affected. A bioactive multiphasic membrane/scaffold with different layers has been advised for this. Until now, few commercial companies using synthetic polymers like polylactic acid (PLA), and woven fibers made up of polyglactin 910 copolymer together with collagen have developed this type of membrane/scaffold. However, different limitations of these materials make their application difficult. MultiphaseGTR focuses on the preparation of bioactive multiphase hydrogel-based biomembrane for periodontal regeneration. The fundamental objectives of the study are: I. Development and characterization of the two components of the biomembrane, i.e., non-mineralized hydrogel and mineralized hydrogel membranes (WP1); II. Preparation of a multiphase hydrogel membrane by combining the two components, i.e., non-mineralized and mineralized hydrogel membranes, and characterization of their physicomechanical properties (WP2); and III. Assessment of the bioactive properties of the multiphase biomembranes in relation to periodontal regeneration (WP3). Finally, a suitable multiphase membrane will be recommended. The outcome of this proposed work not only intends to fill the current gap for the requirement of a suitable cost-effective alternative to the current limited reported materials but also to elaborate the opportunity to increase the knowledge regarding the utilization of biomembrane in dental and maxillofacial tissue regeneration.