MPS_NOVA · MPS NOVA Hub: Advanced Microphysiological Systems and Pluripotent Stem Cell Technologies to Unveil Chronic Disease Mechanisms and Host-Microbe Interactions

Mitigating the current rise in chronic diseases and effectively addressing the enduring challenges posed by infectious diseases are pressing concerns in 21st-century healthcare. These challenges demand innovative research approaches, and microphysiological systems (MPS) have emerged as promising tools for the study of these conditions, as they are capable of replicating near-native human physiology, with significant potential for precision medicine. However, the adoption of MPS technology in Portugal lags behind, primarily due to the high expertise required.To bridge this gap, we will establish a European collaborative network, MPS_NOVA, under the coordination of the University Nova of Lisbon (UNL). This will bring together leading European institutions specializing in MPS and stem cell research, including UKJ (Germany), MDC-BIMSB (Germany), and FHT (Italy). These will collectively offer a broad range of expertise and approaches in the field of MPS and stem cell methodologies, which will fortify UNL's existing multidisciplinary knowledge and expertise, foster best practices in research and training, and expand collaborative networks. By doing so, it will enhance the capabilities, excellence, visibility, and reputation of UNL's research, researchers, and research management staff. For this, a variety of network and research activities have been devised, focusing on the integration of these cutting-edge technologies at UNL, by facilitating collaborative projects and promoting knowledge exchange among partners. Key to these achievements is the upskilling of ITQB NOVA and NMS research managers, who will benefit from tailored partner training in HR excellence, effective management strategies and optimized communication.Together, MPS_NOVA will create a European Center of Excellence in MPS and stem cell research in Portugal, driving breakthrough advances in chronic diseases and host-microbe interactions, benefiting basic and applied research, and society at large.