EURECA · Eukaryotic Regulated RNA Catabolism

Regulation and fidelity of gene expression is fundamental to the differentiation and maintenance of all living organisms. While historically attention has been focused on the process of transcriptional activation, we predict that RNA turnover pathways are equally important for gene expression regulation. This has been implied for selected protein-coding RNAs (mRNAs) but is virtually unexplored for non-protein-coding RNAs (ncRNAs).The intention of the EURECA proposal is to establish cutting-edge research to characterize mammalian nuclear RNA turnover