CARPEDIEM · Cardio Renal Paradigms ElucidateD through an International Exchange ScheMe

CARPEDIEM combines a unique approach and common interest to employ novel sophisticated technologies to understand the relationship between oxygen deprived tissues (hypoxia) and sympathetic hyperactivity in cardiorenal pathology.Cardiovascular diseases are increasing in epidemic proportions globally. Hence there is an essential need for novel insights, ultimately leading to new treatments. The connection between kidneys, heart and brain in cardiovascular pathology offers exciting new research perspectives that are waiting to be explored. We propose that hypoxia in heart, brain and kidneys and the overactivity of sympathetic nervous system is not simply a consequence of cardiovascular disease but rather is intimately involved in driving the progression of disease and loss of tissue function even before any histological damage is apparent.By sharing knowledge and expertise between leading researchers and recognized centres of excellence in Europe, Japan, New Zealand and Australia, we are convinced that significant progress can be achieved in answering important research questions that one institution could never do on its own. Combining our strengths we can now address in a systematic, collaborative and multidisciplinary way the association, induction and reversibility of hypoxia, identify/relate gene expressions and molecular mechanisms in pathological signalling and by using large animal models, computational modelling and imaging in humans translate towards the clinic.This joint international research exchange programme will assist in promoting and reflecting upon knowledge transfer between EU and non-EU countries in order to satisfy the urgent need for new insights in cardiovascular pathophysiology, ultimately leading to new treatment paradigms.